The mysterious Ezekiel Sims is back, and he’s ready to turn Peter Parker’s life upside down once more! As the enigmatic old man pushes Peter to further question the origin of his powers, a being known as Shathra seeks out the web-slinger as her next meal! Can Peter accept Ezekiel’s guidance and unleash the inner spider to destroy this otherworldly predator? 

Next, the origin of Ezekiel’s own spider-powers are revealed, along with the blood debt that must be paid for them. But which spider-totem will pay the price?

Reprinting The Amazing Spider-Man (Vol. 2) #46-50 and #506-508.